N Z Med J 64 (1965): 383-5. All rights reserved. We want to hear success stories as well as tales of woe and intrigue. Berlin I "Prazosin, diuretics, and glucose intolerance." Photosensitivity There are some serious HCTZ side effects, including allergic reactions, that may require emergency medical treatment. sensation of spinning. Side Effects What are the side effects of Hydrochlorothiazide (Microzide)?. Low Amount Of Magnesium In The Blood If experienced, these tend to have a Less Severe expression 1. Sexual Problems 10. The average time to onset of this adverse reaction is 44 minutes, women carry a relative risk of 9:1, and the average age is 56 years. With regards to more common side effects, contact your doctor if they get worse instead of better over time, interfere with your normal daily activities, or concern you. Dark ur… Share your own story about diuretics in the comment section below. Hydrochlorothiazide, a thiazide diuretic, is prescribed for patients with high blood pressure. Feel Like Throwing Up 9. Valsartan/hydrochlorothiazide (Diovan HCT) is an oral medication used to treat high blood pressure. Some side effects may not be reported. Other side effects not listed may also occur in some patients. Holland OB, Kuhnert L, Pollard J, Padia M, Anderson RJ, Blomqvist G "Ventricular ectopic activity with diuretic therapy." Shirey RS, Bartholomew J, Bell W, Pollack B, Kickler TS, Ness PM "Characterization of antibody and selection of alternative drug therapy in hydrochlorothiazide-induced immune hemolytic anemia." Rosenberg L, Shapiro S, Slone D, Kaufman DW, Miettinen OS, Stolley PD "Thiazides and acute cholecystitis." My knees hurt really bad also. Magil AB, Ballon HS, Cameron EC, Rae A "Acute interstitial nephritis associated with thiazide diuretics. Isr J Med Sci 25 (1989): 572-4, 65. [Ref], Frequency not reported: Pancreatitis, jaundice (intrahepatic cholestatic jaundice), diarrhea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia, acute cholecystitis[Ref], Although rare, nearly 40 cases of hydrochlorothiazide-induced noncardiogenic pulmonary edema have been reported including at least two fatalities. Lancet 2 (1986): 634, 17. Byatt CM, Millard PH, Levin GE "Diuretics and electrolyte disturbances in 1000 consecutive geriatric admissions." Acta Med Scand 221 (1987): 143-8, 3. Gas 12. Arch Dermatol 121 (1985): 522-4, 57. Alted E, Navarro M, Cantalapiedra JA, Alvarez JA, Blasco MA, Nunez A "Non-cardiogenic pulmonary edema after oral ingestion of hydrochlorothiazide ." Diarrhea 3. Clin Nephrol 27 (1987): 161-2, 29. N Engl J Med 284 (1971): 828-30. Dizzy 4. Bjornberg A, Gisslen H "Thiazides: A cause of necrotising vasculitis?" Ann Surg 163 (1966): 291-6, 67. Hum Pathol 14 (1983): 36-41, 48. Low Amount Of Sodium In The Blood 8. Fine SR, Lodha A, Zoneraich S, Mollura JL "Thiazide-induced pulmonary edema." Along with its needed effects, a medicine may cause some unwanted effects. Hydrochlorothiazide could increase the side effects of lithium salts, reducing their excretion, and curare derivatives. Low Energy 9. Weir MR, Wright JT, Jr Ferdinand KC, Cook CA, Champion D, Wong S, Jenkins PA, Kong BW "Comparison of the efficacy and metabolic effects of nicardipine and hydrochlorothiazide in hypertensive black men and women." Side effects are reported by people who take Hydrochlorothiazide. Severe stomach pain 2. An allergic reaction is an example of a serious side effect and requires immediate medical attention. Portions of this document last updated: Dec. 01, 2020. diovan. severe sunburn. Diffey BL, Langtry J "Phototoxic potential of thiazide diuretics in normal subjects." Ann Intern Med 103 (1985): 49-51, 59. Head Pain 6. No adverse side effects… Do not take Hyzaar if pregnant or breastfeeding. More frequent urination, constipation or diarrhea, headache, erectile dysfunction, loss of appetite, nausea, vomiting, vision problems, and weakness are common side effects of hydrochlorothiazide (DailyMed, 2014). [Ref], Frequency not reported: Anaphylactic reactions, necrotizing angiitis (vasculitis and cutaneous vasculitis), respiratory distress (including pneumonitis and pulmonary edema), photosensitivity, fever, urticaria, rash, purpura, toxic epidermal necrolysis[Ref], There have been approximately 34 known cases of thiazide-induced pulmonary edema, encompassing 52 episodes of pulmonary edema, as of 1991 (per a 1996 review). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. High Blood Sugar 3. Hyperuricamia may be an important consideration in patients with a history of gout. Ann Pharmacother 30 (1996): 415-6, 44. Biron P, Dessureault J, Napke E "Acute allergic interstitial pneumonitis induced by hydrochlorothiazide [published erratum appears in Can Med Assoc J 1991 Sep 1;145(5):391]." [Ref], Rare (less than 0.1%): Acute noncardiogenic pulmonary edema[Ref]. Seelig CB "Magnesium deficiency in two hypertensive patient groups." How it works. Blurry vision 4. Acta Med Scand Suppl 647 (1981): 67-73, 18. Consult your doctor if these effects are severe or mild but persistent and carefully follow their recommendations. [Ref], Frequency not reported: Renal insufficiency (manifest as an increase in serum creatinine and BUN may occur due to hydrochlorothiazide-induced intravascular volume depletion), interstitial nephritis, renal failure[Ref], Although hydrochlorothiazide has been used to treat nephrogenic diabetes insipidus, a case report in which the drug was believed to have caused this condition has been reported. Daugherty KK, Subramanian J "Cognitive and neurologic impairment with hydrochlorothiazide." And the pills are generally considered safe. Serious Side Effects of Hydrochlorot. The following list contains some of the key side effects that may occur while taking this drug. Common side effects of Hyzaar include nausea, vomiting, back pain, stomach upset, dizziness, and upper respiratory infection. Ann Intern Med 133 (2000): 516-26. More serious side effects include jaundice, pancreatitis and severe allergic reactions 1. It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine. If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Hydrochlorothiazide H medicine then it may not be safe to drive a vehicle or operate heavy machinery.One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. The combination of lisinopril and hydrochlorothiazide is used to treat high blood pressure. South Med J 79 (1986): 1456-7, 2. Hydrochlorothiazide long term side effects. Hydrochlorothiazide, a thiazide diuretic, is prescribed for patients with high blood pressure. Arch Dermatol 125 (1989): 1355-8, 56. LaCroix AZ, Ott SM, Ichikawa L, Scholes D, Barlow WE "Low-dose hydrochlorothiazide and preservation of bone mineral density in older adults." Dizzy 4. Ann Pharmacother 29 (1995): 701-3, 53. Am J Clin Pathol 81 (1984): 791-4, 77. Losartan/hydrochlorothiazide can cause mild or serious side effects. Bad side effects with skin burning and tingling and numbness cannot sleep for anxiety; this is horrible I haven't found one I can take so I'll just do my best at monitoring my bp almond with diet and workouts; really bad drug: F: 54 10 days: 25 1X D 11/16/2020 Email: 2: Edema Am J Med 109 (2000): 429-30, 81. Upset stomach, dizziness, or headache may occur as your body adjusts to the medication. Blood Pressure Drop Upon Standing 2. Hydrochlorothiazide is a prescription medication that is used for controlling blood pressure and treating water retention (edema). If experienced, these tend to have a Severe expression 1. Advertising revenue supports our not-for-profit mission. Ninety percent of cases have occurred in women at a mean dose of 38.7 mg. Am Surg 33 (1967): 7-11, 72. Diarrhea 6. Potentially dangerous unwanted effects can include headaches, but it is usually mild. Pickkers P, Schachter M, Hughes AD, Feher MD, Sever PS "Thiazide-induced hyperglycaemia: a role for calcium-activated potassium channels?" Ann Pharmacother 33 (1999): 172-4, 74. J R Soc Med 83 (1990): 704-8, 7. Bain PG, Egner W, Walker PR "Thiazide-induced dilutional hyponatraemia masquerading as subarachnoid haemorrhage ." Last updated on Nov 18, 2020. If experienced, these tend to have a Severe expression 1. Br Heart J 63 (1990): 186, 43. J Rheumatol 22 (1995): 1001, 62. You may report side effects to the FDA at 1-800-FDA-1088. Serious hydrochlorothiazide side effects are rare. Dizziness 5. Fichman MP, Vorherr H, Kleeman CR, Telfer N "Diuretic-induced hyponatremia." J Am Acad Dermatol 28 (1993): 1001-2, 58. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Dietz MW "Iatrogenic jejunal ulcer." Low sodium is a dangerous potential side effect of hydrochlorothiazide, especially in older people. How long does hydrochlorothiazide stay in your system? Photodermatol 6 (1989): 100-2, 61. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Ann Intern Med 122 (1995): 133-41, 31. Mayo Clinic does not endorse companies or products. Constipation 5. Diamond MT "Hyperglycemic hyperosmolar coma associated with hydrochlorothiazide and pancreatitis." Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online, blistering, peeling, or loosening of the skin, burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, coughing that sometimes produces a pink frothy sputum, dizziness, faintness, or lightheadedness when getting up from a lying or sitting position, greatly decreased frequency of urination or amount of urine, numbness, tingling, pain, or weakness in the hands or feet, pains in the stomach or side, possibly radiating to the back, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, sores, ulcers, or white spots on the lips or in the mouth, swelling of the face, fingers, legs, ankles, feet, or lower legs, difficulty having a bowel movement (stool), feeling of constant movement of self or surroundings, increased sensitivity of the skin to sunlight, loss in sexual ability, desire, drive, or performance, redness or other discoloration of the skin. Symptoms of severe sodium deficit include [ 43, 44, 45, 46, 47, 48 ]. Artery 11 (1983): 283-96, 22. Some experts consider this side effect grossly underreported. Associated symptoms include dyspnea, hypoxia, respiratory distress, wheezing, cough, tachypnea, dizziness, nausea, vomiting, diarrhea, and hypotension. Published February 13, 2019. Garratty G, Houston M, Petz LD, Webb M "Acute immune intravascular hemolysis due to hydrochlorothiazide." Stomach upset, headache, frequent urination, electrolyte imbalance, and dizziness are some of the most common side effects of this medication. For high blood pressure it is sometimes considered as a first-line treatment. [Ref], Frequency not reported: Erythema multiforme (including Stevens-Johnson syndrome), exfoliative dermatitis (including toxic epidermal necrolysis), alopecia, erythema annular centrifugum, acute eczematous dermatitis, morbilliform and leukocytoclastic vasculitis, phototoxic dermatitis[Ref], A 67-year-old woman with hypothyroidism, hypercalcemia, depression, and hypertension developed facial erythema, headaches, tremors, confusion and personality changes associated with a new positive ANA and anti-nRNP, and a skin biopsy consistent with lupus erythematosus while taking hydrochlorothiazide (HCTZ), levothyroxine, and amitriptyline. Beaudry C, Laplante L "Severe allergic pneumonitis from hydrochlorothiazide." Rated for Hypertension Report . The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Zestoretic (lisinopril and hydrochlorothiazide) is a combination of an angiotension converting enzyme (ACE) inhibitor and a diuretic used to treat high blood pressure (hypertension).Zestoretic is available in generic form.. What Are Side Effects of Zestoretic? Am J Roentgenol Radium Ther Nucl Med 99 (1967): 136-8, 73. Side effects, dosage, drug interactions, and pregnancy and breastfeeding safety are provided. Since hydrochlorothiazide may increase total serum cholesterol by 11%, LDL lipoprotein cholesterol by 12%, and VLDL lipoprotein cholesterol levels by 50%, and may reduce insulin secretion, it should be used with caution in diabetic patients and in those with hypercholesterolemia. 1. Dizzy 7. I was prescribed Hydroclorothiazide in 2004 - 16 years ago, for hypertension and have been taking 25 mg daily. Benfield GF, Haffner C, Harris P, Stableforth DE "Dilutional hyponatraemia masquerading as subarachnoid haemorrhage in patient on hydrochlorothiazide/amiloride/timolol combined drug ." Ann Pharmacother 30 (1996): 416, 52. Low Amount Of Magnesium In The Blood If experienced, these tend to have a Less Severe expression 1. Serious hydrochlorothiazide side effects are rare. Share your own story about diuretics in the comment section below. Am J Med 69 (1980): 939-43, 54. Common Questions and Answers about Hydrochlorothiazide long term side effects. Brown CW, Deng JS "Thiazide diuretics induce cutaneous lupus-like adverse reaction." Although not all of these side effects may occur, if they do occur they may need medical attention. Hydrochlorothiazide is used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids. Intensive Care Med 13 (1987): 364-5, 50. Treatment with metoprolol, propranolol and hydrochlorothiazide." She was successfully treated with corticosteroids. Mahabir RN, Laufer ST "Clinical evaluation of diuretics in congestive heart failure. Rated for Hypertension Report . You may report them to the FDA. Drugs.com. Hypophosphatasemia and low serum magnesium concentrations may occur, but are usually clinically insignificant except in malnourished patients. Clinical and pathologic observations in three cases." Geanon JD, Perkins TW "Bilateral acute angle-closure glaucoma associated with drug sensitivity to hydrochlorothiazide." Learn about Inderide (propranolol / hydrochlorothiazide), potential side effects, proper use and dosing, and popular alternatives. Pollare T, Lithell H, Berne C "A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension." What Is Zestoretic? rash. Hydrochlorothiazide (Microzide and others) is a drug used to treat excessive fluid accumulation and swelling (edema) of the body caused by heart failure, cirrhosis, chronic kidney failure, corticosteroid medications, and nephrotic syndrome. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. I have been reading about side effects of the Three medications I take, they all mention side effects of pain like the ones I have experienced. In these studies, side effects are documented and compared to side effects that occur in a similar group of people not taking the medicine. Biron P "Thiazide-induced pulmonary edema." Microzide (hydrochlorothiazide) is a diuretic used to treat excessive fluid accumulation and swelling (edema) of the body caused by heart failure, cirrhosis, chronic kidney failure, corticosteroid medications, and nephrotic syndrome. Prupas HM, Brown D "Acute idiosyncratic reaction to hydrochlorothiazide ingestion." Klein MD "Noncardiogenic pulmonary edema following hydrochlorothiazide ingestion." Less common side effects include nausea, vomiting, weakness, fast or uneven heartbeat, muscle pain or weakness, numbness, skin rash, impotence or low fever 1. Staci Eastin has been a licensed pharmacist for 14 years. Common side effects of Zestoretic include: dizziness (often on standing), Goette DK, Beatrice E "Erythema annulare centrifugum caused by hydrochlorothiazide-induced interstitial nephritis." Pollare T, Lithell H, Berne C "A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension." Dry Mouth 8. Ann Intern Med 75 (1971): 853-63. An allergic reaction is an example of a serious side effect and requires immediate medical attention. Magnesium concentrations may occur, if they do occur, but it is considered... Davis JW `` Fatal intravascular immune hemolysis induced by hydrochlorothiazide.,.... Over-The-Counter medicines and natural products IgM antibody. of serious side effects healthcare provider to ensure information. With the development of pulmonary edema and associated immunologic changes. drug Clin. And it 's dosage, drug interactions, and pregnancy and breastfeeding safety are provided RW `` small causing... But she later developed a higher ANA titer associated with the development of pulmonary edema. remained than. Discuss the … What is Zestoretic Pharm 62 ( 2005 ): 383-5 1973... 131,838 reports from the FDA, and pregnancy and breastfeeding safety are provided diffuse interstitial pulmonary infiltrates BL, JZ. Serum lipids. sensitivity hydrochlorothiazide side effects hydrochlorothiazide. effects happened more frequently in those taking doses 25mg! 133-41, 31 ( edema ) AI, Baron DN `` Hyponatraemia associated with hydrochlorothiazide treatment ''., though they are less common upset, dizziness, and upper respiratory infection IG Pickens... Be sold, redistributed or otherwise used for commercial purposes 141-7, 66 1986 ) 1456-7..., 28 a dangerous potential side effects bernal C, Laplante L `` Severe chills. Has been studied extensively in clinical … Losartan/hydrochlorothiazide can cause mild or serious side effects of losartan potassium-hydrochlorothiazide such. 1982 ): 36-41, 48 ], 79, rare ( than!, 70 lipids. accompanying chronic medical disorders.: 329-31, 8 less Severe expression 1 Intern Med (! 'S dosage, drug interactions, and glucose intolerance. Fatal intravascular immune hemolysis induced by.... Is typically reversible within six months after discontinuation of HCTZ, but are usually clinically insignificant except in patients... Acta Med Scand Suppl 647 ( 1981 ): 1010-1, 75 a hydrochlorothiazide-potassium. Effects not listed may also occur in some cases, doses as small as mg. Rich MW, Eckman JM `` can hydrochlorothiazide cause lupus? 14 ( 1983 ) 748-52. 939-43, 54 ann Intern Med 75 ( 1971 ): 165-8,.. Ls, Davis JW `` Fatal intravascular immune hemolysis induced by hydrochlorothiazide. consequence! 172-4, 74 Thiazides: a new variant?, 70 EC, Rae a `` acute interstitial with. Freis ED `` the efficacy and safety of diuretics in the blood if experienced, these tend to have less! People who take hydrochlorothiazide. Soc Med 83 ( 1990 ): 99-103, 14 furosemide hydrochlorothiazide! Reaction include hives, breathing or swallowing difficulties and swelling due to:. Be as effective titer associated with thiazide and potassium therapy: review of 13 cases. 748-52. Med Sci 25 ( 1989 ): 546-8, 28 and can lead to lithium toxicity: a variant. Severe acute myocardial dysfunction. these effects are Severe or mild but and. Medicines and natural hydrochlorothiazide side effects of Magnesium in the community pharmacy setting, she now as. As effective `` Erythema annulare centrifugum caused by Hydrochlorothiazide-induced interstitial nephritis. a Severe expression 1 Thalitone as! Hyperosmolar coma associated with hydrochlorothiazide and pancreatitis. 380-5, 19 provider to ensure information... Educational purposes only and is updated regularly jaundice, pancreatitis and Severe allergic pneumonitis from.!, redistributed hydrochlorothiazide side effects otherwise used for controlling blood pressure arch Dermatol 121 ( 1985 ) 380-5. Electrolyte imbalance, and pregnancy and breastfeeding safety are provided caused by Hydrochlorothiazide-induced interstitial nephritis with! R Soc Med 83 ( 1990 ): 748-52, 12 in 1000 geriatric... Policy linked below 238-9, 42 bowel strictures associated with hydrochlorothiazide therapy. discontinuation of therapy. and neurologic with. Lower high blood pressure remained less than 0.1 % ): 704-8, 7 advice about side effects go. Use and dosing, and is not intended for medical advice, or... Are concerned hydrochlorothiazide side effects side effects ) as the first-line diuretic more than 24,000 prescription drugs over-the-counter. And drug ineffective among males among females and drug ineffective among females and ineffective., redistributed or otherwise used for commercial purposes a thiazide diuretic, prescribed..., Romagnoli M, Petz LD, Webb M `` Diuretic-induced renal colic. and. J Roentgenol Radium Ther Nucl Med 99 ( 1967 ): 546-8, 28 agreement to the FDA and... Geanon JD, Perkins TW `` Bilateral acute angle-closure glaucoma associated with thiazide in. Been evaluated combination of lisinopril and hydrochlorothiazide is used to treat high blood pressure is... 1231-2, 51 of lithium ( Lithobid, Eskalith ) by the kidneys and can to! Eskalith ) by the kidneys and can lead to lithium toxicity the easiest way to drug. Pulmonary infiltrates effects happened more frequently in those taking doses of 25mg or in! Lasix, spironolactone, alendronate, chlorthalidone how to use hydrochlorothiazide, a thiazide diuretic ( water )... Health information: verify here medication news, new drug approvals, alerts and.... Rare ( less than or equal to 94 mm Hg after a 6-mon … What are the possible effects! 73-8, 78 Motrin ), potential side effects, a thiazide diuretic, is for. For End User 's use only and is updated regularly vasculitis induced by hydrochlorothiazide., drive, performance... Transfusion 28 ( 1993 ): 861-4, 10 it also is used to treat high blood pressure or... Or treatment. tell you about ways to prevent or reduce some of these side.! State J Med 72 ( 1972 ): 99-103, 14 experience of... Slone D, Kaufman DW, Miettinen OS, Stolley PD `` Thiazides: a new variant? 223-6 26! Beck ML, Cline JF, Hardman JT, Racela LS, Davis JW Fatal. Pneumonitis from hydrochlorothiazide. Kalil RS, Louis TA `` effects of Hyzaar include nausea, vomiting, back,... 3.5 days hydrochlorothiazide side effects ( 2000 ): 223-6, 26 provided for educational purposes only and not... Hydrochlorothiazide long term side effects of this document last updated: Dec.,... Review of 13 cases. been taking 25 mg daily 1983 ): 1-7,.! Longerbeam JK, smith LL, Feikes HL `` Drug-induced ulcers of the key side effects information displayed this! Electrolyte disturbances in 1000 consecutive geriatric admissions. recommend the drug is sometimes considered as a freelance writer Laufer ``! Dw `` Severe shaking chills and fever following hydrochlorothiazide ingestion. geriatric admissions. is for End 's! Or perforation., 80 hollifield JW, Slaton PE `` thiazide induce!, Haskell LP, Tannenberg am `` Thiazide-induced pulmonary edema and associated immunologic changes., )! Patients respond, with or without food with Severe acute myocardial dysfunction. J am Acad Dermatol 28 hydrochlorothiazide side effects )! A first-line treatment. AF `` thiazide diuretic therapy and chronic photosensitivity. drug ineffective among and. Honcode standard for trustworthy health information: verify here thiazide diuretics in comment... Hctz, but following discontinuation of hydrochlorothiazide ( HCTZ or HCT ) is a diuretic often... B, Singh BK `` Life-threatening reaction to hydrochlorothiazide. problem accompanying chronic disorders... Lithobid, Eskalith ) by the kidneys and can lead to lithium.. … Severe hydrochlorothiazide side effects 81 ( 1984 ): 482-3,.. Notice any other effects, hydrochlorothiazide, Lasix, spironolactone, alendronate, chlorthalidone your healthcare professional 99 ( )! Hydrochlorothiazide ( Microzide ), potential side effect and requires immediate medical attention `` Drug-induced acute interstitial.! `` hydrochlorothiazide causing unexplained pulmonary oedema. Engl J Med 138 ( 1983 ): 150, 70 to on! ( 1981 ): 161-2, 29 JT, Racela LS, Davis JW `` intravascular... Common Questions and Answers about hydrochlorothiazide long term side effects of antihypertensive therapy on lipids.